Modulation of functional connectivity during the resting state and the motor task.

 
Hum Brain Mapp. 2004 May;22(1):63-71.

Modulation of functional connectivity during the resting state and the motor task.

National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China. jiangtz@nlpr.ia.ac.cn
Quite a few studies in functional magnetic resonance imaging (fMRI) have tested that, even in a resting state, motor cortices constitute a network. It has never been investigated how the network modulates from the resting state to the motor task state. In this report, by a newly developed approach taking into account n-to-1 connectivity using 1-to-1 connectivity measures instead of conventional pairwise connectivity, we show the existence of a large organized functional connectivity network related to motor function in the resting brain with fMRI. More importantly, we found that such a network can be modulated from a conscious resting state to planning, initiation, coordination, guidance, and termination of voluntary movement state, exhibited by significant changes of functional connectivity of some brain regions in different brain activity. Moreover, a quantitative description of such a functional modulation has also been presented. Copyright 2004 Wiley-Liss, Inc.

PMID:  15083527  [Click to show in PubMed]

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