Resting-state fMRI topics

最近，一直用ICA处理静息态的数据，突然被人问及了一个这样的问题。确实不知道该怎么回答。

Since the global signal tends to affect the default network connectivity map, why did your NOT try to remove such global effect before the ICA analysis?

WIN XP； Matlab7.01； rest 1.4（20100426）；

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Hello,

I´m very new in Rest, I have only one Patient and I want to see the activation areas in resting state, I already got the ALFF, fALFF and Reho, and I tried with the Slice Viewer, but when I choose the T1 image for the overlay, the next message appears:

This NIfTI image includes an rotation transformation. You should reslice this data before attempting to overlay the image,

严老师：

您好！我在进行slice timing 时出现故障，提示如下：
The following modules did not run:
Failed: Slice Timing

??? Error using ==> cfg_util>local_runcj at 1426
Job execution failed. The full log of this run can be found in MATLAB command window, starting with the lines
(look for the line showing the exact #job as displayed in this error message)
------------------
Running job #1

Welcome to the PhD thesis defense of two PhD candidates

8:30, April 12, 3rd floor meeting room, MRI center, State Key Lab of Cognitive Neuroscience and Learning, BNU

1. Miss Qihong Zou. Resting-State Functional magnetic Resonance Imaging---Based on BOLD and ASL Techniques.
2. Mr. Chaogan Yan. The spontaneous brain activity: resting-state fMRI network studies.

严老师：
您好。我以PCC为种子点得到了正常组跟病例组的FC值，用zFC分别做了单样本T检验和双样本的T检验。正常组与PCC相关的脑区与文献相同，病例组得到的相关脑区要少于正常组，但是做了双样本T检验之后发现，病例组在单样本T检验没有出现激活的脑区，现在出现了激活，正值负值都有。例如海马旁回和枕叶，单样本的病例组并未出现任何激活区，但是做完双样本时候海马旁回出现了负值，而枕叶却出现了正值。请问这是什么原因呢？是不是我的数据有问题？该如何分析这种情况？谢谢。